File Extension PRL File Format Perl Script PRL stands for Perl Script. This was last updated in March 2012 By Margaret Rouse Browse File Extensions Alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # Ask a Question. Find an Answer. Ask your peers a question about this file extension. Ask a Question Help with perl script to add information to AD user profile Unix/Shell/PERL scripting on AS/400 Suggest one OS Cert and one scripting language.