File Extension PYTHON File Format Python Script ( Python Software Foundation ) PYTHON stands for Python Script ( Python Software Foundation ). This was last updated in March 2012 By Margaret Rouse Browse File Extensions Alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # Ask a Question. Find an Answer. Ask your peers a question about this file extension. Ask a Question Change Microsoft Excel font size using Python How to take a screenshot through a Python script Access and Python?