Responsive design makes it possible for a web page or app to detect the visitor’s screen size and orientation and automatically adapt the display accordingly; the mobile first approach assumes that smartphones, tablets and task-specific Mobile apps are employees' primary tools for getting work done and addresses the requirements of those technologies in design.
Bootstrap includes user interface components, layouts and JS tools along with the framework for implementation. The software is available precompiled or as source code.
Mark Otto and Jacob Thornton developed Bootstrap at Twitter as a means of improving the consistency of tools used on the site and reducing maintenance. The software was formerly known as Twitter Blueprint and is sometimes referred to as Twitter Bootstrap.
In computers, the word bootstrap means to boot: to load a program into a computer using a much smaller initial program to load in the desired program (which is usually an operating system).
In the physical world, a bootstrap is a small strap or loop at the back of a leather boot that enables you to pull the entire boot on and in general usage, bootstrapping is the leveraging of a small initial effort into something larger and more significant. There is also a common expression, "pulling yourself up by your own bootstraps," meaning to leverage yourself to success from a small beginning.
Watch a crash course on creating a website with Bootstrap: